Methyl B-12 provides Vitamin B-12 in its active state, which makes it more biologically available to the body. While vitamin B-12 can be obtained from the diet as two dietary forms; methylcobalamin and 5-deoxyadenosylcobalamin via synthesis by intestinal flora, and stored in the liver, supplementation is preferable for those suffering from a methylation defect. 

Because our bodies contain only a very small amount of vitamin B-12 (2-5 mg), reserves can become depleted easily due to malnutrition, lack of intrinsic factor in the gut, or mal-absorption. Symptoms of Vitamin B-12 deficiency may include fatigue, anemia, vascular headaches, gastrointestinal issues, cognitive difficulties and low mood.*